![]() Magnesium is a mineral necessary for electrical stability of every cell in the body. It not only has no critical adverse effect, but also can protect patients from other AEDs severe side effects and hopefully it also makes it possible to gradually decrease the dose of AEDs in long-term combination therapy.” But it has to be mentioned the metabolism of curcumin between human and rats are different and humans can tolerate high doses of this medicine without significant side effects. It has been demonstrated to be safe in animal studies in a number of species. “Curcumin-the major extract of turmeric has found to have antiepileptic effect according to recent investigations. ![]() Herbal medicine has been presented to be a safe adjuvant therapy with lower cost and better outcome. It is a potent inhibitor of reactive astrocyte expression.Īn experimental review of the effect of curcumin on epilepsy published in Reviews in Clinical Medicine concluded: “ Epilepsy is one of the worldwide important diseases, which both the seizure frequency and the treatment with antiepileptic drugs (AEDs) affect the quality of life of patients and many suffer from the consequences. The neuro-protective properties of curcumin prove beneficial in treating epilepsy. ![]() Curcumin possess antidepressant activity, modulating the release of serotonin and dopamine associated with feelings of well-being.Ĭurcumin enhances the level of brain derived neurotrophic factor, which acts on certain neurons of the central nervous system. The low molecular weight and polar structure of curcumin allows it to penetrate into the blood-brain barrier effectively. The curcumin found in turmeric proves beneficial in treating epilepsy. In Nigeria, it is called atale pupa in Yoruba gangamau in Hausa nwandumo in Ebonyi ohu boboch in Enugu (Nkanu East) gigir in Tiv magina in Kaduna turi in Niger State onjonigho in Cross River (Meo tribe). Turmeric is a spice that comes from the root of Curcuma longa, a member of the ginger family, Zingaberaceae. So dopamine and 5-HT might play an important role in the anti-cataleptic and antiepileptic activity of the ethanolic extract of MP.” 5-HT1A receptors are reduced in the ipsilateral hippocampus in temporal-lobe epilepsy patients. Increased serotonin immune-reactivity has been reported in human epileptic brain tissue resected for the control of epilepsy. Dopamine acts as a neuro-protective agent in epilepsy. Dopamine is used for treatment of catalepsy. The researchers concluded: “The leaves of MP are reported to contain dopamine and 5-HT. The seeds of MP are reported to possess anti-cataleptic activity. It also acts as a neuro-protective agent in epilepsy. ![]() pruriens (MP) are also reported to contain dopamine. The plant Mucuna pruriens has high content of dopamine in seeds. It belongs to the plant family Fabiaceae.Ī study published in Indian Journal of Pharmacology has confirmed the anticataleptic and antiepileptic activity of ethanolic extract of leaves of Mucuna pruriens. Previous studies in our laboratories and elsewhere have shown that the fruit of Tetrapleura tetraptera is widely used in African traditional medicine for the management and/or control of an array of human ailments, including schistosomiasis, asthma, epilepsy, hypertension and so on.Ĭommonly called Velvet bean or Cowhage, Mucuna pruriens is known as werepe in Yoruba and agbala or agbaloko in Ibo. These findings lend pharmacological support to the suggested folkloric uses of the plant’s fruit in the management and/or control of painful, arthritic inflammatory conditions, as well as for the management and/or control of epilepsy and childhood convulsions in some tropical African countries.” ![]() Results of a study published in Phytotherapy Research concluded: “Tetrapleura tetraptera fruit aqueous extract (TTE) possesses analgesic and anticonvulsant properties. It is locally known as aridan among the Yoruba, osakirisa or oshosho among the Igbo, dawo among the Hausa, all in Nigeria, and is also referred to as prekese among the Twi people of Ghana. Tetrapleura tetraptera belongs to the Mimosaceae/Fabacae family. ![]()
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